As a nutritionist you get always surprised when something that you recommended to one of your clients did exactly what your client told you. Sometimes I think they might be a placebo effect when the improvement is so quick, but I must admit that it is possible.
One of my clients, a while back, said that vitamin B12 sublingual made a huge difference from the moment they took it. Now I thought, well the research mention that it might take few weeks to see a big improvement with sublingual or even with B12 injections, which by the way, sublingual and injections seems to have the same quick effect, so I now might choose the sublingual instead.
I had a series of little things recently, which started from my digestions of food, not as noticeable that I thought of a problem, as everything seems to be ok. I did have a bit of stress due to my dog passed away this year, but I did not think that stress and sadness would turn into a healthy issue, even though I should know better. As usual as therapist we think we are invincible and always ok.
Anyway, I did a good liver detox, digestions make over, food and diet a bit healthier than before (pretty healthy, already), a bit more soups and stew, with plenty of vegetables, nutritious proteins and good fats, and plenty of liver detox support supplements. That made my digestions and liver very, very happy. Now due to the liver and digestions problems, my immune system went down, with more viral infections that I usually have.
The last one is the one that is going around, the sore throat and flu. I manage it again with lots of vitamin C and other immune support. But still could not shift it, even with steam and lots of throat support and gargles with salt and water, and more, it seems my body immunity did not fight back quickly enough.
At some point I was much better, but still at night I would have this irritate cough and a sensation that a frog was stuck in my throat, I decide to go and buy some oregano to support my immune system with the vitamin C and a multi vitamin support. I could not find the oregano but for some nutritional instinct I decided to buy a sublingual Vitamin B12. I took 2 sachets of it of a total of about 500 microgram and within less than 10 minutes my irritate frog went completely, to my amazement, my mucus was loose and little. I thought was only my imagination, but did not have any cough at night and woke up still ok. I feel myself again. Now ideally would want to check my B12, but I am not vegetarian and I thought that might be normal. Eventually I will but could be that is going to be private, as the NHS right now is a bit annoying for appointments.
I looked more into the B12, and in reality, the fact that I had a stomach issue, due to low stomach acid, might have stopped the intrinsic factor and the R factor to transport my B12 into the cells.
Now I will explain a bit more about the absorption, and function of the B12 in more details, for everyone to understand the reason why everyone, from vegan to meat eaters can be low in B12, even though B12 is stored for years, if it is not transported into the cells, it is like you have none.
B12, unlike any other water B vitamins that are excreted every few hours from your body, is stored in the liver, with vitamin D, E and A.
Sources of vitamin B12 are only from animal products, any vegetarian source is by contact with animal or cross contamination or fortified vegetarian food, included cereals. Now the source of fortified food depends on the quality and the form of the B12.
B12 has a corrin nucleus and is part of the groups called corrinoids. This is a macrocyclic ring made of four reduced pyrrole rings linked together, this will carry an atom of cobalt, hence quite often you will see the name of the B12 as cyanocobalamin, hydrocobalamin, and Methylcobalamin and more. The methylcobalamin are the active form as coenzymes for many functions in the body.
Bioavailability of B12 can be impaired by vitamin C, so if you take B12 with a high or low dosage of vitamin C together at the same time or up to 1 hour after meal, such as 500mg, you stop from the B12 to work and be absorbed.
Digestion, absorption, transport and storage of vitamin B12:
Once the B12 is ingested from food, it needs to be released from the enzyme pepsin in the stomach (the stomach acid needs to be working well for the pepsin to be secreted, low stomach acid, will impair the secretion of pepsin and hence, B12 is not going to be released from the food, even if you are a meat eaters or eggs eater).
Also with stress, there is no signal to the stomach to release and activate pepsin to digest the proteins. The vagal nerve, is involved in the digestion process, too much into stress mode or sympathetic mode, will stop your full and healthy digestion, hence my stress or sadness caused by the loss of a dog, who was very dear to me, caused my stress, which caused my low stomach acid, which caused my B12 malfunction, which caused my immunity to go down, and so forth. Connecting the dots……
Once B12 is released from the food ingested, it needs two proteins for working. One is the intrinsic factor (IF) and the other is the R proteins. The IF is again made by the gastric cells (made again with a good and healthy stomach acid). IF is made and released by the stomach during a healthy digestion and works in the small intestine. The R proteins are everywhere in the body fluids, and have a high affinity for cobalamin. R will pick up the free cobalamin and transport it to the duodenum, first part of the small intestine, where the pancreatic juices will release the B12 again, unless you have a pancreatic insufficiency, (low enzyme activity) and again the B12 will not be released into the small intestine for transport into the blood stream. Again, if something goes wrong no B12.
In the proximal small intestine, the IF will pick up the freed B12 and transport it to the ileum, where receptors for B12 will wait for it to be transported into the blood stream. IF can transport B12 through the entire ileum and receptors are everywhere in the small intestine.
It seems that calcium ions is an essential mineral for the absorption of B12 into the blood stream.
From normal ingestion of food with B12, the process of absorption might take 3 to 4 hours before is in the blood stream.
As I mentioned before, B12 is the only one that can be stored in the liver for a long time and even years, and it is also found in small amount in kidneys, spleen, bone, heart and brain.
Now if children are vegan from weaning, and they are not given extra B12 supplementation from early age, there is a possibility that the child will be low in B12, which possible serious issues with their growth.
Some of the Function of B12:
- Co-enzyme for the conversion of homocysteine into methionine.
- Essential for the maintenance of the protective sheath surrounding nerves, hence, essential for the good function of the nervous system.
- Has a key role for the making of a healthy red blood cell, hence essential for circulation and healthy blood.
- Is a co-enzyme for one of the steps in making the ATP, the energy fuel for your cells, in the Kreb cycle, the energy nuclear power, in the mitochondria (where fuel for your body is formed, the CoA mutase).
- It is part of the making of the serotonin in your body, the feeling good neurotransmitter, hence important for the health of the brain and mood.
- Essential vitamin for making and repairing of DNA. This is essential for your life, really. The methylation part is an essential step for the DNA building block and the repair of damaged DNA. Without a sufficient B12, the DNA building and repair will be severely disrupted.
- Supports also the normal function of the immune system. This is done by promoting white blood cells maturation and formation, as well as synthesis of division and replication of the DNA for the immune system.
- Essential during pregnancy to prevent birth defect, with folate, this promotes cells division and DNA formation of the baby.
- Essential for the health of the bones, through the synthesis of taurine, an amino acid essential for bone formation. There is also a positive correlation with good amount of B12 function and bone density.
- B12 for the eyes, is essential for the myelin sheath of the eyes, reduces dry eyes and reduction of oxidative stress, as well as inflammation.
Tests for B12 deficiency due to IF deficiency is a full blood count, which will measure serum B12 and some active B12.
An anti-intrinsic factor antibody test can be suggested for pernicious anaemia (autoimmune disease) or megaloblastic anaemia (big red blood cell).
Other tests are also recommended with folate as well.
As you have seen from the B12 ingestion, absorption, transportation and life of the B12, this is not just another B vitamin, is an essential vitamin for your health and life.
If you are vegan or you have children that are also vegan, do consider for life to have B12 sublingual supplementation, to make sure that your children will grow well without health issues, and you, yourself, is healthy.
Even as a meat eaters, if you have low stomach acid, or you are taking medication to reduce your stomach acid, if you had a gastric bypass, or you have any issues with digesting your food, pancreatic issues, bile issue, or constant stress, cannot sleep due to stress, have or had a bereavement, moved houses, or changed your lifestyle or you are the last person that you think about, due to overwhelming responsibility, than think about testing for B12 or even take for a while a sublingual B12 with folate if possible.
If you are pregnant and vegan, do take the vitamin, sublingual, as you have seen the long process and possible problems that the normal digestive journey of the B12 is, and possibly in a normal tablet form, will not reach the blood stream due to any of the digestive system problems.








